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Signal Transduction Pathways

Several hundred protein phosphorylation signal transduction pathways have been elucidated over the last 30 years. Many of these can be retrieved from the “Signal Transduction Weblinks” that are provided here. Cell signalling can proceed through sequential protein phosphorylation, but the transient and stable interactions between proteins and their spatial redistributions are other important parameters in understanding how intracellular messages are disseminated in cells. Furthermore, the architecture of a signalling pathway is very dependent on the availability of its various possible components in each cell type. Kinexus is seeking to create a high resolution atlas of human cell signalling networks that takes into account cell/tissue type, gender, age and health status. Such an ambitious project requires advancements on many fronts. We believe that the accumulation of protein-based information of cell signalling protein levels and phosphorylation status is an important step for such an endeavor. This is why we provide our proteomics services, and why we make much of our results available to the scientific community from our KiNET functional proteomics databank.
With our internal bioinformatics programs, we hope to convert this wealth of data into practical knowledge and understanding of human cell signalling systems.

To assist researchers in improving their knowledge of the complexity of cell signalling, Kinexus is pleased to make freely available signal transduction pathway slides we call “Pathimations” in Microsoft PowerPoint format for non-profit educational purposes. These slides were produced by Dr. Steven Pelech at Kinexus and they are copyrighted for commercial purposes. As signal transduction pathways can be extremely elaborate and complicated, it is often difficult to show all of the relevant connections in a static image. Each “Pathimation” provides a relatively simple conceptual presentation of a key signalling system with a series of connecting slides with build functions so that it is semi-animated. Each frame is annotated with an explanation of the steps in the signalling system depicted. It is possible for users to customize these slides for their own teaching, but they should acknowledge Kinexus visually on each slide.
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Human Epidermal Growth Factor Receptor Signalling

Download Powerpoint file EGF_Receptor-Network.ppt
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Human cGMP-dependent Protein Kinase Signalling

Download Powerpoint file PKG_Signalling.ppt
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Human cAMP-dependent Protein Kinase Signalling

Download Powerpoint file PKA_Signalling.ppt
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Human Glycogen Regulation

Download Powerpoint file GlycogenRegulation.ppt