Kinexus Corporate Animations

Animations from various Kinexus presentations.

Animation	Title And Description
	Kinexus Drug Discovery Click here to view.
	Kinexus Intro Click here to view.
	Kinexus World Click here to view.

Signal Transduction Proteins in Multimeric Complexes – Space Filling Models

These animations feature rotating 3D x-ray crystallographic structures of representative signalling proteins in complexes, which have been separately colourized to facilitate their visualization.

Download a full legend to protein chain colorization and detailed references for all the signal transduction proteins shown in animations immediately below (ADOBE PDF FORMAT)

Animation	Title And Description
	1A0N Nfat, Fos and Jun DNA-binding domains bound to DNA Click here to view.
	1A02 Fyn tyrosine kinase SH3 domain complexed with a synthetic peptide P2L corresponding to residues 91-104 of the p85 subunit of phosphatidylinositol 3- kinase Click here to view.
	1A37 14-3-3 bound to Raf kinase Ser-259 phosphorylation site containing peptide Click here to view.
	1A6Q Protein-serine/threonine phosphatase 2C (PP2C) Click here to view.
	1AMP cAMP-dependent protein kinase (PKA) catalytic subunit complexed with inhibitor portion of PKI inhibitor Click here to view.
	1AXC Proliferating cell nuclear antigen (PCNA) binding to p21 WAF CDK inhibitor Click here to view.
	1B17 Insulin A and B chains in a complex Click here to view.
	1BUH Cyclin-dependent kinase 2 (CDK2) complex with cell cycle-regulatory protein Ckshs1 Click here to view.
	1CS4 Adenylate Cyclase C1A and C2A domains complexed with Gs alpha subunit Click here to view.
	1CVS Fibroblast growth factor 2 (FGF2) dimer - fibroblast growth factor receptor1 (FGFR1) complex Click here to view.
	1CXZ RhoA complexed with the effector domain of the protein kinase PKN/PRK1 Click here to view.
	1D0G Death receptor 5 (DR5) extracellular domain bound to Apo2 ligand/Trail Click here to view.
	1E0A_2 Cdc42 complexed with the GTPase binding domain of p21-activated kinase (PAK) Click here to view.
	1E0O Fibroblast growth factor 1 (FGF1) dimer - fibroblast growth factor receptor 2 (FGFR2) complex Click here to view.
	1EBA_2 Erythropoietin (Epo) receptor extracellular domain bound to Epo Click here to view.
	1EFN HIV-1 Nef protein in complex with Arg- 96I mutant Fyn SH3 Domain Click here to view.
	1ES7 Bone morphogenetic protein (BMP) receptor Ia extracellular domain bound to BMP-2 Click here to view.
	1F1J Caspase-7 in complex with Acetyl-Asp- Glu-Val-Asp-Cho Click here to view.
	1FAP FKBP12-rapamycin complex interacting with PI3K-related kinase FRAP fragment Click here to view.
	1FPR SHP-1 tyrosine phosphatase catalytic domain and an in vitro peptide substrate Py469 derived from SHPS-1 Click here to view.
	1FQ1 Cyclin-dependent kinase 2 (CDK2) complexed with KAP Click here to view.
	1G1F Protein tyrosine phosphatase 1B (PTP1B) complexed with a tri- phosphorylated peptide (Rdi(Ptr) Etd(Ptr)(Ptr)Rk) from the insulin receptor kinase Click here to view.
	1G3N p18(Ink4C)-cyclin-dependent kinase 6 - cyclin K ternary complex Click here to view.
	1G6R Superagonist T cell antigen receptor (TCR)/major histochemistry complex (MHC) Click here to view.
	1GNG Glycogen synthase kinase-3 (GSK3) complex with Frattide peptide Click here to view.
	1GOT Trimeric G protein complex of alpha, beta and gamma subunits Click here to view.
	1H10 Pleckstrin homology domain of Protein Kinase B/Akt bound to Ins(1,3,4,5)- tetrakisphosphate Click here to view.
	1H9O Phosphatidylinositol 3-kinase (PI3K), p85- subunit: C-terminal SH2 domain complexed with a Tyr-751 phosphorylation site containing peptide from the platelet-derived growth factor receptor Click here to view.
	1HE8 Ras G12V - Phosphatidylinositol 3- kinase (PI3K) complex Click here to view.
	1I51 Caspase-7 in complex with Xenopus inhibitor of apoptosis (XIAP) Click here to view.
	1IRU Mammalian 20S proteasome complex Click here to view.
	1ITB Interleukin-1 (IL1) type-1 receptor complexed with interleukin-1 beta Click here to view.
	1JSU Cyclin-dependent kinase 2 (CDK2)/cyclin A complexed with p27 KIP1 Click here to view.
	1JWH Casein kinase 2 (CK2) holoenzyme alpha and beta subunit quaternary complex Click here to view.
	1KX3 Histones H2A, H2B, H3 and H4 with DNA in nucleosomes core complexes Click here to view.
	1KZ0 Protein farnesyltransferase complexed with farnesylated K- Ras4B peptide product and farnesyl diphosphate substrate bound simultaneously Click here to view.
	1LAR LAR receptor tyrosine phosphatase tandem phosphatase domains Click here to view.
	1MF8 Calcineurin (PP2B)-calmodulin - cyclophilin-cyclosporin complex Click here to view.
	1N8Z ErbB2 (HER2) receptor tyrosine kinase extracelleular domain complexed with herceptin monoclonal antibody Fab fragment Click here to view.
	1NT9 RNA polymerase 2 complex Click here to view.
	1NVV Ras-GTP of the Ras-specific nucleotide exchange factor Sos Click here to view.
	1O6K Protein kinase B/Akt kinase domain S474D complexed with glycogen synthase kinase 3 peptide and AMP-PnP Click here to view.
	1OWM G protein coupled receptor kinase 2 (GRK2/BARK) complexed with G- beta/gamma subunits Click here to view.
	1P9M Interleukin-6 (IL6) alpha/interleukin-6 beta receptorand interleukin-6 Click here to view.
	1PNX 30S Ribosome RNA and protein complex Click here to view.
	1PNY 50S Ribosome RNA and protein complex Click here to view.
	1Q4K Polo-like kinase 1 (PLK1) polo-box domain in a complex with a phospho- peptide Click here to view.
	1RQQ Insulin receptor tyrosine kinase in a complex with the SH2 domain of adapter APS anda substrate inhibitor Click here to view.
	1SHC Shc PTB domain complexed with a phosphopeptide from the TrkA receptor- tyrosine kinase Click here to view.
	1TUP Tumor suppressor p53 complexed with DNA Click here to view.
	1WQ1 Ras complexed with Ras-GTPase activating protein (GAP) Click here to view.
	1WWW Nerve growth factor in complex with domain 5 of the TrkA receptor-tyrosine kinase Click here to view.
	2NGR Cdc42 bound to the active and catalytically compromised forms of the Cdc42-GTPase activating protein (GAP) Click here to view.
	CAM2 Calmodulin-dependent kinase 2 oligomer complexed with calmodulin (artistic composite - (CaMK2 catalytic domain represented with phosphorylase kinase catalytic domain) Click here to view.
	egfr Epidermal growth factor (EGF) receptor- tyrosine kinase domain dimer shown with plasma membrane and extracellular EGF domain (artistic composite) Click here to view.

Signal Transduction Proteins – Ribbon, Stick and Ball 3D Models

These animations feature rotating 3D x-ray crystallographic structures of cell signalling proteins with ribbon, stick and ball representation to facilitate their visualization.

Download a full legend to protein chain colorization and detailed references for all the signal transduction proteins shown in animations immediately below (ADOBE PDF FORMAT)

Animation	Title And Description
	1B39 Cyclin-dependent kinase 2 (CDK2) with Thr-160 phosphorylation site - ball model Click here to view.
	1D5R PTEN phosphoinositide phosphatase - ribbon model Click here to view.
	1DM2 CDK2 complexed marine sponge inhibitor hymenialdisine - ball model Click here to view.
	1E0A Cdc42 complexed with the GTPase binding domain of p21-activated kinase-alpha (PAKa) - stick model Click here to view.
	1E8Z Phosphatidylinositol 3-kinase gamma (PI3Kg) p110 catalytic subunit bound with inhibitor staurosporin - ribbon Click here to view.
	1EBA Erythropoietin (Epo) receptor extracellular domain bound to Epo - ball model Click here to view.
	1F3M p21-activated kinase-alpha (PAKa) autoregulatory domaincomplexed with its catalytic domain - ball and ribbon model Click here to view.
	1FAO 1FAO Click here to view.
	1FMK Src protein-tyrosine kinase with SH2, SH3, catalytic domain and C-terminus - wire model Click here to view.
	1FMK Src protein-tyrosine kinase - ribbon model Click here to view.
	1FYN Fyn protein-tyrosine kinase SH3 domain with proline-containing polypeptide from 3BP-2 - ball model Click here to view.
	1GRI Growth factor bound protein 2 (Grb2) - ribbon model Click here to view.
	1IAN p38 MAPK alpha - ball model Click here to view.
	1IR3 Insulin receptor-tyrosine kinase catalytic domain with peptide substrate - stick model Click here to view.
	1MCO Immunoglobulin - ball model Click here to view.
	1NTS DNA double helix - stick model Click here to view.
	1PTU Protein-tyrosine phosphatase 1B complexed with a phosphotyrosine-containing hexapeptide - stick model Click here to view.
	1QB0 Cdc25B dual specificty phosphatase - ribbon model Click here to view.
	1QB3 Cyclin-dependent kinase regulatory subunit (Cks1) - ball model Click here to view.
	1QJA 14-3-3 zeta dimer complexed with Raf1 phosphorylated serine-containing peptide - stick and ball model Click here to view.
	1QMZ Cyclin-dependent kinase 2 (CDK2) complexed with cyclin A - ribbon and ball model Click here to view.
	1RVD H-Ras small G protein G12V constitutively active mutant - ribbon model Click here to view.
	1WQ1 Ras complexed with Ras-GTPase activating protein (GAP) - ribbon model Click here to view.
	1ZEH Insulin - ball model Click here to view.
	2CSN Casein kinase 1 (CK1) catalytic subunit - ribbon model Click here to view.
	2HNP Protein-tyrosine phosphatase 1B - ribbon model Click here to view.
	4ERK Extracellular-regulated kinase 2 (ERK2) complexed with drug - ribbon model Click here to view.
	4Q21 H-Ras small G protein - inactive form bound to GDP - ribbon model Click here to view.

Conserved Amino Acids in Catalytic Domains of Signal Transduction Proteins

These animations feature rotating 3D x-ray crystallographic structures of representative signalling proteins in complexes, which have been separately colourized to facilitate their visualization.

Download a full legend to protein chain colorization and detailed references for all the signal transduction proteins shown in animations immediately below (ADOBE PDF FORMAT)

Animation	Title And Description
	1QTN Human Caspase 8 p18 (Residues 211-374) Human Caspase 8 p11 (Residues 385-473) (light grey) Substrate Peptide - IETD (dark grey) Click here to view.
	1J4X (Residues 211-374) Click here to view.
	1AS0 Rat G Protein Gi?1 (Residues 1-353) Click here to view.
	1CJK (Residues 385-473) (light grey) Substrate Peptide - IETD (dark grey) Click here to view.
	1UHO Human cGMP-Specific 3’,5’-Cyclic Phosphodiesterase Catalytic Fragment Levitra (black) (Residues 537-860) Click here to view.
	1E7V Pig Phosphatidylinositol 3-Kinase p110 Catalytic Subunit Click here to view.
	1BBC Human Phospholipase A2 - IIA Click here to view.
	1DJX Rat Phosphoinositide-Specific Phospholipase C-delta1 complexed with Inositol-1,4,5-trisphosphate Click here to view.
	1M17 Human Epidermal Growth Factor Receptor Tyrosine Kinase Catalytic Domain Click here to view.
	1AUI4 Human Protein-Serine Phosphatase 2B Calcineurin complexed with Calmodulin Click here to view.
	1G1G Human Protein-Tyrosine Phosphatase 1B complexed with ETDYpYRKGGKGLL peptide from 1-866-kinexus TOLL FREE PHONE Insulin Receptor Click here to view.
	121P Human H-Ras (Residues 1-166) Click here to view.
	1QTN Human Caspase 8 p18 (Residues 211-374) Human Caspase 8 p11 (Residues 385-473) (light grey) Substrate Peptide - IETD (dark grey) Click here to view.

Signalling Protein Reaction Pathways

These animations feature rotating 3D x-ray crystallographic structures of representative signalling proteins in complexes, which have been separately colourized to facilitate their visualization.

Animation	Title And Description
	AdrenRecGProtAdeCycl Beta-adrenergic receptor activation of G proteins and stimulation of adenylate cyclase for production of cAMP Click here to view.
	ANFRecept.cGMPSignalling Atrial naturitic factor induced dimerization of ANF receptor and activation of guanylate cyclase activity for production of cGMP Click here to view.
	cAMP-Dep.KinaseActivation cAMP activation of cAMP-dependent protein kinase Click here to view.
	CytokinesBathingCell Distant view of cytokines bathing and activating a spherical cell Click here to view.
	PDGFRecept.Signalling Platelet-derived growth factor induced dimerization and phosphorylation of PDGF receptor and activation of cell signalling Click here to view.
	ProteinPhosph_Reaction2 Protein phosphorylation reaction - A nano-satellite telemetry view - A kinase takes ATP and phosphorylates a protein substrate Click here to view.
	ProteinPhosph.Reaction1 Protein phosphorylation reaction - A kinase takes ATP and phosphorylates a protein substrate Click here to view.
	TGFbetaRecept.Signaling Transforming growth factor-beta induced dimerization and phosphorylation of TGF-beta receptor and activation of cell signalling Click here to view.