Reviews

Towards complete sets of farnesylated and geranylgeranylated proteins.
Maurer-Stroh S, Koranda M, Benetka W, Schneider G, Sirota FL, Eisenhaber F.
PLoS Comput Biol. 2007 Apr 6;3(4):e66.
http://compbiol.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pcbi.0030066

Development of farnesyl transferase inhibitors: a review.
Appels NM, Beijnen JH, Schellens JH.
Oncologist. 2005 Sep;10(8):565-78.
http://theoncologist.alphamedpress.org/cgi/content/full/10/8/565

Ubiquitin signalling in the NF-kappaB pathway.
Chen ZJ.
Nat Cell Biol. 2005 Aug;7(8):758-65.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16056267

The biology and enzymology of protein N-myristoylation.
Farazi TA, Waksman G, Gordon JI.
J Biol Chem. 2001 Oct 26;276(43):39501-4.
http://www.jbc.org/cgi/content/full/276/43/39501

A tale of histone modifications.
Grant PA.
Genome Biol. 2001;2(4):REVIEWS0003.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11305943

Comparative proteomic and transcriptomic profiling of the fission yeast Schizosaccharomyces pombe.
Schmidt MW, Houseman A, Ivanov AR, Wolf DA.
Mol Syst Biol. 2007;3:79.
http://www.nature.com/doifinder/10.1038/msb4100117

Global analysis of protein phosphorylation in yeast.
Ptacek J, Devgan G, Michaud G, Zhu H, Zhu X, Fasolo J, Guo H, Jona G, Breitkreutz A, Sopko R, McCartney RR, Schmidt MC, Rachidi N, Lee SJ, Mah AS, Meng L, Stark MJ, Stern DF, De Virgilio C, Tyers M, Andrews B, Gerstein M, Schweitzer B, Predki PF, Snyder M.
Nature. 2005 Dec 1;438(7068):679-84.
http://www.nature.com/nature/journal/v438/n7068/abs/nature04187.html

KESTREL: a powerful method for identifying the physiological substrates of protein kinases.
Cohen P, Knebel A.
Biochem J. 2006 Jan 1;393(Pt 1):1-6.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16336195

Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP.
Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15302935

Kinomics: methods for deciphering the kinome
Johnson SA, Hunter T.
Nat Methods. 2005 Jan;2(1):17-25.
http://www.nature.com/nmeth/journal/v2/n1/abs/nmeth731.html

Phosphoproteomic analysis of the developing mouse brain.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP.
Mol Cell Proteomics. 2004 Nov;3(11):1093-101.
http://www.mcponline.org/cgi/content/full/3/11/1093

A prototype antibody microarray platform to monitor changes in protein tyrosine phosphorylation.
Gembitsky DS, Lawlor K, Jacovina A, Yaneva M, Tempst P.
Mol Cell Proteomics. 2004 Nov;3(11):1102-18.
http://www.mcponline.org/cgi/content/full/3/11/1102

Protein kinase function and glutathionylation.
Anselmo AN, Cobb MH.
Biochem J. 2004 Aug 1;381(Pt 3):e1-2.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15270699

Molecular genetic perspectives on cross-talk and specificity in abiotic stress signalling in plants.
Chinnusamy V, Schumaker K, Zhu JK.
J Exp Bot. 2004 Jan;55(395):225-36.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=

Archaeal protein kinases and protein phosphatases: insights from genomics and biochemistry.
Kennelly PJ.
Biochem J. 2003 Mar 1;370(Pt 2):373-89.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12444920

Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors.
Kholodenko BN.
J Exp Biol. 2003 Jun;206(Pt 12):2073-82
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12756289

Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM.
Mol Cell Proteomics. 2005 Sep;4(9):1240-50.
http://www.mcponline.org/cgi/content/full/4/9/1240

Structural basis and prediction of substrate specificity in protein serine/threonine kinases.
Brinkworth RI, Breinl RA, Kobe B.
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):74-9.
http://www.pnas.org/cgi/content/full/100/1/74

Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins.
Dodge-Kafka KL, Langeberg L, Scott JD.
Circ Res. 2006 Apr 28;98(8):993-1001.
http://circres.ahajournals.org/cgi/content/full/98/8/993

Akt1 in endothelial cell and angiogenesis.
Somanath PR, Razorenova OV, Chen J, Byzova TV.
Cell Cycle. 2006 Mar;5(5):512-8.
http://www.landesbioscience.com/journals/cc/abstract.php?id=2538

Mammalian sterile 20-like kinases in tumor suppression: an emerging pathway.
O'Neill EE, Matallanas D, Kolch W.
Cancer Res. 2005 Jul 1;65(13):5485-7. Links
http://cancerres.aacrjournals.org/cgi/content/full/65/13/5485

Rho-kinase is an important therapeutic target in cardiovascular medicine.
Shimokawa H, Takeshita A.
Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1767-75.
http://atvb.ahajournals.org/cgi/content/full/25/9/1767

PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.
Dong LQ, Liu F.
Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E187-96.
http://ajpendo.physiology.org/cgi/content/full/289/2/E187

Neuronal Ca2+/calmodulin-dependent protein kinase II--discovery, progress in a quarter of a century, and perspective: implication for learning and memory.
Yamauchi T.
Biol Pharm Bull. 2005 Aug;28(8):1342-54.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16079472&query_hl=5

The multiple personalities of the regulatory subunit of protein kinase CK2: CK2 dependent and CK2 independent roles reveal a secret identity for CK2beta.
Bibby AC, Litchfield DW.
Int J Biol Sci. 2005;1(2):67-79. Epub 2005 Apr 1.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=

A-kinase-anchoring proteins.
Langeberg LK, Scott JD.
J Cell Sci. 2005 Aug 1;118(Pt 15):3217-20.
http://jcs.biologists.org/cgi/content/full/118/15/3217

The activation of Akt/PKB signaling pathway and cell survival.
Song G, Ouyang G, Bao S.
J Cell Mol Med. 2005 Jan-Mar;9(1):59-71.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15784165&query_hl=5

Caught Nek-ing: cilia and centrioles.
Quarmby LM, Mahjoub MR.
J Cell Sci. 2005 Nov 15;118(Pt 22):5161-9.
http://jcs.biologists.org/cgi/content/full/118/22/5161

The survival kinases Akt and Pim as potential pharmacological targets.
Amaravadi R, Thompson CB.
J Clin Invest. 2005 Oct;115(10):2618-24.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16200194

Protein kinase cascades in the regulation of cardiac hypertrophy.
Dorn GW 2nd, Force T.
J Clin Invest. 2005 Mar;115(3):527-37.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15765134&query_hl=5

Role of JNK activation in apoptosis: a double-edged sword.
Liu J, Lin A.
Cell Res. 2005 Jan;15(1):36-42.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15686625&query_hl=5

Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein.
Trakul N, Rosner MR.
Cell Res. 2005 Jan;15(1):19-23.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15686621&query_hl=5

IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy.
Luo JL, Kamata H, Karin M.
J Clin Invest. 2005 Oct;115(10):2625-32.
http://www.jci.org/cgi/content/full/115/10/2625

WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension.
Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, Cobb MH.
Cell Res. 2005 Jan;15(1):6-10.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15686619&query_hl=5

Amyloid pathology and protein kinase C (PKC): possible therapeutics effects of PKC activators.
Olariu A, Yamada K, Nabeshima T.
J Pharmacol Sci. 2005 Jan;97(1):1-5. Epub 2005 Jan 15.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15655301&query_hl=5

Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets.
Kwon G, Marshall CA, Pappan KL, Remedi MS, McDaniel ML.
Diabetes. 2004 Dec;53 Suppl 3:S225-32.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15561916&query_hl=5

The AMP-activated protein kinase pathway--new players upstream and downstream.
Hardie DG.
J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15509864&query_hl=5

AKAP (A-kinase anchoring protein) domains: beads of structure-function on the necklace of G-protein signalling.
Malbon CC, Tao J, Shumay E, Wang HY.
Biochem Soc Trans. 2004 Nov;32(Pt 5):861-4.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15494034&query_hl=5

Glycogen synthase kinase 3beta and the regulation of axon growth.
Goold RG, Gordon-Weeks PR.
Biochem Soc Trans. 2004 Nov;32(Pt 5):809-11.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15494021&query_hl=5

Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?
Patel S, Doble B, Woodgett JR.
Biochem Soc Trans. 2004 Nov;32(Pt 5):803-8.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15494020&query_hl=5

Distinctive activation mechanisms and functions for protein kinase Cdelta.
Steinberg SF.
Biochem J. 2004 Dec 15;384(Pt 3):449-59.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15491280&query_hl=5

Linking JNK signaling to NF-kappaB: a key to survival.
Papa S, Zazzeroni F, Pham CG, Bubici C, Franzoso G.
J Cell Sci. 2004 Oct 15;117(Pt 22):5197-208.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15483317&query_hl=5

Wiring diagrams of MAPK regulation by MEKK1, 2, and 3.
Uhlik MT, Abell AN, Cuevas BD, Nakamura K, Johnson GL.
Biochem Cell Biol. 2004 Dec;82(6):658-63.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15674433&query_hl=37

Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes.
Clerk A, Sugden PH.
Biochem Cell Biol. 2004 Dec;82(6):603-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15674427&query_hl=37

Order or chaos? An evaluation of the regulation of protein kinase CK2.
Olsten ME, Litchfield DW.
Biochem Cell Biol. 2004 Dec;82(6):681-93.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15674436&query_hl=37

RNA interference and double-stranded-RNA-activated pathways.
Sledz CA, Williams BR.
Biochem Soc Trans. 2004 Dec;32(Pt 6):952-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15506933&query_hl=37

The genetics of Pak.
Hofmann C, Shepelev M, Chernoff J.
J Cell Sci. 2004 Sep 1;117(Pt 19):4343-54.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15331659&query_hl=37

AMP-activated protein kinase: the guardian of cardiac energy status.
Hardie DG.
J Clin Invest. 2004 Aug;114(4):465-8.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15314681&query_hl=37

Upstream and downstream of mTOR.
Hay N, Sonenberg N.
Genes Dev. 2004 Aug 15;18(16):1926-45.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15314020&query_hl=37

ATM and ataxia telangiectasia.
McKinnon PJ.
EMBO Rep. 2004 Aug;5(8):772-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15289825&query_hl=37

MAP kinases as structural adaptors and enzymatic activators in transcription complexes.
Edmunds JW, Mahadevan LC.
J Cell Sci. 2004 Aug 1;117(Pt 17):3715-23.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15286173&query_hl=37

Protein kinase function and glutathionylation.
Anselmo AN, Cobb MH.
Biochem J. 2004 Aug 1;381(Pt 3):e1-2.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15270699&query_hl=37

Physiology and pathophysiology of vascular signaling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase.
Birschmann I, Walter U.
Acta Biochim Pol. 2004;51(2):397-404.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15218537&query_hl=37

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.
Roux PP, Blenis J.
Microbiol Mol Biol Rev. 2004 Jun;68(2):320-44.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15187187&query_hl=37

Oxidative neuronal injury. The dark side of ERK1/2.
Chu CT, Levinthal DJ, Kulich SM, Chalovich EM, DeFranco DB.
Eur J Biochem. 2004 Jun;271(11):2060-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15153095&query_hl=37

Role of extracellular signal regulated kinase 5 in neuronal survival.
Cavanaugh JE.
Eur J Biochem. 2004 Jun;271(11):2056-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15153094&query_hl=37

Role of extracellular signal regulated kinases 1 and 2 in neuronal survival.
Hetman M, Gozdz A.
Eur J Biochem. 2004 Jun;271(11):2050-5.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15153093&query_hl=37

The enigmatic protein kinase Cdelta: complex roles in cell proliferation and survival.
Jackson DN, Foster DA.
FASEB J. 2004 Apr;18(6):627-36.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15054085&query_hl=37

Physiological functions of protein kinase B/Akt.
Yang ZZ, Tschopp O, Baudry A, Dummler B, Hynx D, Hemmings BA.
Biochem Soc Trans. 2004 Apr;32(Pt 2):350-4.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15046607&query_hl=37

Yang J, Xu ZP, Huang Y, Hamrick HE, Duerksen-Hughes PJ, Yu YN.
ATM and ATR: sensing DNA damage.
World J Gastroenterol. 2004 Jan 15;10(2):155-60.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14716813&query_hl=37

Tasken K, Aandahl EM.
Localized effects of cAMP mediated by distinct routes of protein kinase A.
Physiol Rev. 2004 Jan;84(1):137-67.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14715913&query_hl=37

MAP kinases in the mammalian circadian system--key regulators of clock function.
Coogan AN, Piggins HD.
J Neurochem. 2004 Aug;90(4):769-75.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=

ATM and ATR: sensing DNA damage.
Yang J, Xu ZP, Huang Y, Hamrick HE, Duerksen-Hughes PJ, Yu YN.
World J Gastroenterol. 2004 Jan 15;10(2):155-60.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14716813&itool=iconfft

From signal to cell polarity: mitogen-activated protein kinases as sensors and effectors of cytoskeleton dynamicity.
Samaj J, Baluska F, Hirt H.
J Exp Bot. 2004 Jan;55(395):189-98.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14673033

PKC at a glance.
Parker PJ, Murray-Rust J.
J Cell Sci. 2004 Jan 15;117(Pt 2):131-2.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14676268

The structural perspective on CDK5.
Mapelli M, Musacchio A.
Neurosignals. 2003 Sep-Oct;12(4-5):164-72.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14673202

Role of Cdk5 in neuronal signaling, plasticity, and drug abuse.
Bibb JA.
Neurosignals. 2003 Sep-Oct;12(4-5):191-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14673205

Cdk5 in neuroskeletal dynamics.
Smith D.
Neurosignals. 2003 Sep-Oct;12(4-5):239-51.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14673211

The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways.
Houslay MD, Baillie GS.
Biochem Soc Trans. 2003 Dec;31(Pt 6):1186-90.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14641023

Bypassing the glucose/fatty acid cycle: AMP-activated protein kinase.
Carling D, Fryer LG, Woods A, Daniel T, Jarvie SL, Whitrow H.
Biochem Soc Trans. 2003 Dec;31(Pt 6):1157-60.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14641016

Cdk5 and the mystery of synaptic vesicle endocytosis.
Nguyen C, Bibb JA.
J Cell Biol. 2003 Nov 24;163(4):697-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14638853

Protein kinase C: a target for anticancer drugs?
Mackay HJ, Twelves CJ.
Endocr Relat Cancer. 2003 Sep;10(3):389-96.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14503915

Akt is a molecular target for signal transduction therapy in brain ischemic insult.
Fukunaga K, Kawano T.
J Pharmacol Sci. 2003 Aug;92(4):317-27.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12939516

The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines.
White E.
Genes Dev. 2003 Aug 1;17(15):1813-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12897050

A-kinase anchoring proteins and neuronal signaling mechanisms.
Carnegie GK, Scott JD.
Genes Dev. 2003 Jul 1;17(13):1557-68. Review.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12842908

Unravelling the activation mechanisms of protein kinase B/Akt.
Scheid MP, Woodgett JR.
FEBS Lett. 2003 Jul 3;546(1):108-12.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12829245

LKB1, a protein kinase regulating cell proliferation and polarity.
Boudeau J, Sapkota G, Alessi DR.
FEBS Lett. 2003 Jul 3;546(1):159-65.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12829253

cAMP effector mechanisms. Novel twists for an 'old' signaling system.
Kopperud R, Krakstad C, Selheim F, Doskeland SO.
FEBS Lett. 2003 Jul 3;546(1):121-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12829247

Management of cellular energy by the AMP-activated protein kinase system.
Hardie DG, Scott JW, Pan DA, Hudson ER.
FEBS Lett. 2003 Jul 3;546(1):113-20.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12829246

Protein kinase D: a family affair.
Rykx A, De Kimpe L, Mikhalap S, Vantus T, Seufferlein T, Vandenheede JR, Van Lint J.
FEBS Lett. 2003 Jul 3;546(1):81-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12829240

NDR family of AGC kinases--essential regulators of the cell cycle and morphogenesis.
Tamaskovic R, Bichsel SJ, Hemmings BA.
FEBS Lett. 2003 Jul 3;546(1):73-80.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12829239

Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38.
Clark AR, Dean JL, Saklatvala J.
FEBS Lett. 2003 Jul 3;546(1):37-44.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12829234

Targeting Aurora-2 kinase in cancer.
Warner SL, Bearss DJ, Han H, Von Hoff DD.
Mol Cancer Ther. 2003 Jun;2(6):589-95.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12813139

AIP1: a new player in TNF signaling.
Guicciardi ME, Gores GJ.
J Clin Invest. 2003 Jun;111(12):1813-5.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12813014

Biphasic role of TGF-beta1 in signal transduction and crosstalk.
Wenner CE, Yan S.
J Cell Physiol. 2003 Jul;196(1):42-50.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12767039

Have we overlooked the importance of serine/threonine protein phosphatases in pancreatic beta-cells? Role played by protein phosphatase 2A in insulin secretion.
Parameswara VK, Sule AJ, Esser V.
JOP. 2005 Jul 8;6(4):303-15.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16006680&query_hl=145

Regulation of calcineurin, a calcium/calmodulin-dependent protein phosphatase, in C. elegans.
Bandyopadhyay J, Lee J, Bandyopadhyay A.
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The role of serine/threonine protein phosphatases in exocytosis.
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Protein tyrosine phosphatases: the quest for negative regulators of insulin action.
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Receptor protein tyrosine phosphatases in nervous system development.
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New twist on neuronal insulin receptor signaling in health, disease, and therapeutics.
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The PI3-K/Akt pathway: roles related to alterations in vasomotor responses in diabetic models.
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J Smooth Muscle Res. 2005 Dec;41(6):283-302.
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JOP. 2005 Jul 8;6(4):303-15.
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Biochem Soc Trans. 2004 Nov;32(Pt 5):817-21.
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Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling.
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Grb10 adapter protein as regulator of insulin-like growth factor receptor signaling.
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Control of glycogen deposition.
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Three-dimensional structural interactions of insulin and its receptor.
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Phosphoinositide-derived messengers in endocrine signaling.
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Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling.
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Regulation of nuclear phospholipase C activity.
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Phospholipase D.
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The MARCKS family of phospholipid binding proteins: regulation of phospholipase D and other cellular components.
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Biochem Cell Biol. 2004 Feb;82(1):191-200.
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Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment.
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Phosphoinositide 3-kinase: the protein kinase that time forgot.
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Cellular function of calcium-independent phospholipase A2.
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Regulatory mechanism and physiological role of cytosolic phospholipase A2.
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Regulation of nuclear phospholipase C activity.
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The mechanism of action of the tumour suppressor gene PTEN.
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Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Nov;147(1):19-25.
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PIKE GTPase: a novel mediator of phosphoinositide signaling.
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Molecular mechanisms regulating hormone-sensitive lipase and lipolysis.
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The phosphoinositide (PI) 3-kinase family.
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Phosphoinositide 3-kinase-dependent activation of Rac.
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Phosphoinositide signaling disorders in human diseases.
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Activation of multiple cancer-associated genes at the ERBB2 amplicon in breast cancer.
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Role of receptor tyrosine kinases in gastric cancer: new targets for a selective therapy.
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mTOR-targeted therapy of cancer with rapamycin derivatives.
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Anti-tumor chemotherapy utilizing peptide-based approaches--apoptotic pathways, kinases, and proteasome as targets.
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Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer.
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Signaling by target of rapamycin proteins in cell growth control.
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Raf kinase as a target for anticancer therapeutics.
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The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective.
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BRAF mutation in thyroid cancer.
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Cancer treatment with kinase inhibitors: what have we learnt from imatinib?
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Angiogenesis inhibitors in clinical development; where are we now and where are we going?
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Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal.
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Is there a role for epidermal growth factor receptor inhibitors in breast cancer prevention?
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Blocked pathways: FTIs shut down oncogene signals.
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Signal events: Cell signal transduction and its inhibition in cancer.
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Activation of tyrosine kinases in cancer.
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Identification of surrogate markers for determining drug activity using proteomics.
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The Her-2/neu gene and protein in breast cancer 2003: biomarker and target of therapy.
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Phorbol esters and neurotransmitter release: more than just protein kinase C?
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Molecular footprints of human lung cancer progression.
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Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.
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Novel role and regulation of the interleukin-1 receptor associated kinase (IRAK) family proteins.
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Cell Mol Immunol. 2005 Feb;2(1):36-9.
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NF-kappaB signaling in lymphocytes: a new cast of characters.
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Signalling networks, inflammation and innate immunity.
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T-cell integrins: more than just sticking points.
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Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases.
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Selectivity and potency of cyclin-dependent kinase inhibitors.
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Green light for the cell cycle.
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Restarting the cell cycle when the checkpoint comes to a halt.
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Secrets of a double agent: CDK7 in cell-cycle control and transcription.
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Cyclin D1: Normal and Abnormal Functions.
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Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development.
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Checkpoint responses to replication stalling: inducing tolerance and preventing mutagenesis.
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Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts.
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Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways.
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Phosphorylation of serine 10 in histone H3, what for?
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Regulation of microtubule organization during interphase and M phase.
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Apoptosis - the p53 network.
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The anti-apoptotic response of the Gq/11-coupled muscarinic receptor family.
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Toll-like receptor signaling.
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Overcoming resistance of cancer cells to apoptosis.
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Control of Ras cycling by Ca2+.
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Regulation of cell proliferation, apoptosis, and carcinogenesis by activin.
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Rho GTPases and the control of cell behaviour.
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Control of Ras cycling by Ca2+.
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Guanine nucleotide exchange factors for Rho GTPases: turning on the switch.
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The interface of receptor trafficking and signalling.
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Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton.
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