Host: Allen Institute for Brain Science, Seattle, WA, USA

Features: The Allen Brain Atlas (ABA) is an interactive, genome-wide image database of gene expression in the mouse brain. A combination of RNA in situ hybridization data, detailed Reference Atlases and informatics analysis tools are integrated to provide a searchable digital atlas of gene expression.

Host: European Bioinformatics Institute (EBI)

Features: ArrayExpress is a public repository for microarray data, which is aimed at storing well annotated data in accordance with The Microarray Gene Expression Data (MGED) Society recommendations.

Host: Blueprint and Mt. Sinai Hospital, Toronto

Features: BIND is a collection of records documenting molecular interactions. The contents of BIND include high-throughput data submissions and hand-curated information gathered from the scientific literature.

Host: National Center for Biotechnology Information, Bethesda, MD, USA

Features: BLAST finds regions of local similarity between sequences. The program compares nucleotide or protein sequences to sequence databases and calculates the statistical significance of matches. BLAST can be used to infer functional and evolutionary relationships between sequences as well as help identify members of gene families.

Host: National Cancer Institute, Bethesda, MD, USA

Features: The NCI's Cancer Genome Anatomy Project seeks to determine the gene expression profiles of normal, precancer, and cancer cells, leading eventually to improved detection, diagnosis, and treatment for the patient. The websites' interconnected modules provide access to all CGAP data, bioinformatic analysis tools, and biological resources allowing the user to rapidly find "in silico" answers to biological questions.

Host: Royal Society of Chemistry

Features: ChemSpider is a free access service providing access to millions of chemical structures and integration to a multitude of other online services.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: ChEBI is a freely available dictionary of molecular entities focused on ‘small’ chemical compounds. The term ‘molecular entity’ refers to any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer, etc., identifiable as a separately distinguishable entity. The molecular entities in question are either products of nature or synthetic products used to intervene in the processes of living organisms.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: Clustal W is a general purpose multiple sequence alignment program for DNA or proteins.It produces biologically meaningful multiple sequence alignments of divergent sequences. It calculates the best match for the selected sequences, and lines them up so that the identities, similarities and differences can be seen. Evolutionary relationships can be seen via viewing Cladograms or Phylograms.

Host: Swiss Institute of Bioinformatics, Geneva, Switzerland

Features: Compute pI/Mw is a tool which allows the computation of the theoretical pI (isoelectric point) and Mw (molecular weight) for a list of Swiss-Prot and/or TrEMBL entries or for a user entered sequence.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: The Catalytic Site Atlas (CSA) is a resource of catalytic sites and residues identified in enzymes using structural data.

Host: EMBL EBI and Institute of Biotechnology, University of Helsinki, Finland

Features: The Dali server is a network service for comparing protein structures in 3D.

Host: National Center for Biotechnology Information, Bethesda, MD, USA

Features: The NCBI website features a listing of known single nucleotide polymorphisms in human genes.

Host: United Kingdom MRC Human Genetics Unit in Edinburgh, Scotland

Features: The emap Atlas is a digital Atlas of mouse embryonic development. It features a series of interactive three-dimensional computer models of mouse embryos at successive stages of development with defined anatomical domains linked to a stage-by-stage ontology of anatomical names.

Host: National Center for Biotechnology Information, Bethesda, MD, USA

Features: This webportal provides a very extensive list of websites that provide bioinformatics tools and databases.

Host: National Center for Biotechnology Information, Bethesda, MD, USA

Features: The Entrez CDD can be searched to identify proteins that share a conserved interaction domain. It features a collection of multiple sequence alignments for ancient domains and full-length proteins.

Host: National Center for Biotechnology Information, Bethesda, MD, USA

Features: Entrez Gene is a searchable database of genes, from RefSeq genomes, and defined by sequence and/or located in the NCBI Map Viewer. It does not include all known or predicted genes; instead Entrez Gene focuses on the genomes that have been completely sequenced, that have an active research community to contribute gene-specific information, or that are scheduled for intense sequence analysis. The content (nomenclature, map location, gene products and their attributes, markers, phenotypes, and links to citations, sequences, variation details, maps, expression, homologs, protein domains and external databases) is updated as new information becomes available.

Host: National Center for Biotechnology Information, Bethesda, MD, USA

Features: The Entrez Nucleotides database is a collection of sequences from several sources, including GenBank, RefSeq, and PDB. The number of bases in these databases (well over 130 billion) continues to grow at an exponential rate.

Host: National Center for Biotechnology Information, Bethesda, MD, USA

Features: Entrez - SNP permits searches for SNP's in genes.

Host: National Center for Biotechnology Information, Bethesda, MD, USA

Features: The protein entries in the Entrez search and retrieval system have been compiled from a variety of sources, including SwissProt, PIR, PRF, PDB, and translations from annotated coding regions in GenBank and RefSeq.

Host:

Features: A curated database of 22,000 monclonal antibody products, hundreds of thousands of product information pages submitted by reagent providers, millions of webpages selected from all 700 reagent suppliers and over 200,000 bioscience-related websites. Antibodies are organized according to genes, species, reagent types (antibodies, phospho-specific antibodies, recombinant proteins, ELISA, siRNA, etc.), patents, and researchers.

Host: Weizmann Institute of Science and Xennex, Inc.

Features: GeneCards is a database of human genes, their products and their involvement in diseases. It offers concise information about the functions of human genes.

Host: National Institutes of Health, Bethesda, MD, USA

Features: The GeneTests Web site is a publicly funded medical genetics information resource developed for physicians, other healthcare providers, and researchers. It contains online publication of expert-authored disease reviews and other educational resources such as a glossary.

Host: National Center for Biotechnology Information, Bethesda, MD, USA

Features: Gene Expression Omnibus is a gene expression/molecular abundance repository supporting MIAME compliant data submissions, and a curated, online resource for gene expression data browsing, query and retrieval.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: The Gene Ontology (GO) Consortium is an international collaboration among scientists at various biological databases, with an Editorial Office based at the EBI. GOA is a project that aims to provide assignments of gene products to the Gene Ontology (GO) resource. The objective of GO is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products. These terms are to be used as attributes of gene products by collaborating databases, facilitating uniform queries across them.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: The GOA project aims to provide high-quality Gene Ontology (GO) annotations to proteins in the UniProt Knowledgebase (UniProtKB) and International Protein Index (IPI) and is a central dataset for other major multi-species databases; such as Ensembl and NCBI.

Host: National Center for Biotechnology Information, Bethesda, MD, USA

Features: HomoloGene is a system for automated detection of homologs among the annotated genes of several completely sequenced eukaryotic genomes.

Host: Albanova University Center at the Royal Institute of Technology (KTH, Stockholm) and the Rudbeck Laboratories (Uppsala University), Sweden

Features: The HPR atlas has been created to show the expression and localization of proteins in a large variety of normal human tissues and cancer cells. The data is presented as high resolution images representing immunohistochemically stained tissue sections. Available proteins (genes) can be reached through a specific search (by gene/protein name/id or classification, such as kinase or protease) or by browsing the individual chromosomes.

Host: Kazusa DNA Research Institute, Chiba, Japan

Features: The HUGE protein database focuses on the analysis of cDNA clones encoding particularly large proteins (>50 kDa). The database contains various types of information derived from the predicted primary structure data of newly identified human proteins.

Host: Human Proteome Organization Initiative Based in Stockholm and Uppsala, Sweden

Features: The human protein atlas displays expression and localization of proteins in a large variety of normal human tissues and cancer cells. The data is publically available and presented as high resolution images of immunohistochemically stained tissues and cell lines with over 1500 antibodies and over 1.2 million images.

Host: The Bioinformatics Group at the IMP Vienna, Austria

Features: HumanPRENbase is a derivate of PRENbase with focus on human prenylated proteins. In PRENbase, paralogous proteins are clustered together in their respective larger family when they are highly similar to each other. A scheme of reciprocal BLASTs were employed in order to identify the true orthologues of a set of prenylated human proteins. 238 individual human proteins and their orthologues form the clusters in HumanPRENbase.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: IntAct is a protein interaction database and analysis system. It provides a query interface and modules to analyse interaction data.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: InterPro is a database of protein families, domains and functional sites in which identifiable features found in known proteins can be applied to unknown protein sequences.

Host: Protein Information Resource located at Georgetown University Medical Center

Features: The iProClass is an integrated resource that provides comprehensive family relationships and structural/functional features of proteins.

Host: Jena Centre for Bioinformatics,Jena, Germany

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: The Ontology Lookup Service is a spin-off of the PRIDE project, which required a centralized query interface for ontology and controlled vocabulary lookup. While many of the ontologies queriable by the OLS are available online, each has its own query interface and output format.

Host: British Columbia Cancer Agency in Vancouver, Canada

Features: The Atlas shows the normal state for many tissues by determining, in a comprehensive and quantitative fashion, the number and identity of genes expressed throughout development. It's scope encompasses multiple stages of development, from the single cell zygote to the adult, and includes an extensive initial collection of 200 tissues.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: The Ontology Lookup Service is a spin-off of the PRIDE project, which required a centralized query interface for ontology and controlled vocabulary lookup. While many of the ontologies queriable by the OLS are available online, each has its own query interface and output format.

Host: NCBI - John Hopkins University, Baltimore, MD, USA

Features: OMIM is a catalogue of human genes and genetic disorders, authored and edited by staff and scientists at Johns Hopkins University. The database is richly populated with links to PubMed citations, sequence data, and genetic information connected with the gene in question. Information on knockout organisms, overexpression studies and expression in normal and disease states can also be found here, depending on the gene.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: PANDIT - Protein and Associated Nucleotide Domains with Inferred Trees. PANDIT is a collection of multiple sequence alignments and phylogenetic trees covering many common protein domains.

Host: Research Collaboratory for Structural Bioinformatics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA

Features: PDB contains the single worldwide repository for the processing and distribution of 3-D biological macromolecular structure data.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: PDBsum provides an at-a-glance overview of every macromolecular structure deposited in the Protein Data Bank (PDB), giving schematic diagrams of the molecules in each structure and of the interactions between them.

Host: Wellcome Trust Sanger Institute, Hinxton, UK

Features: Pfam is a large collection of over 8000 multiple sequence alignments and hidden Markov models covering many common protein domains and families. Each family in Pfam can be examined for multiple alignments, protein domain architectures and structures and species distribution.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK, Cellzome and others

Features: The Phospho.ELM database contains a collection of experimentally verified Serine, Threonine and Tyrosine sites in eukaryotic proteins. The entries, manually annotated and based on scientific literature, provide information about the phosphorylated proteins and the exact position of known phosphorylated instances.

Host: Cell Signaling Technology Company, Beverly, MA, USA

Features: PhosphoSite contains a very comprehensive list of many of the known human and mouse protein phosphorylation sites with very extensive supporting information.

Host: Georgetown University Medical Center, Washington, DC, USA

Features: The Protein Information Resource (PIR) is an integrated public bioinformatics resource to support genomic and proteomic research, and scientific studies. PIR has made many protein databases and analysis tools freely accessible to the scientific community.

Host: Center for Information Biology and DNA Data Bank of Japan National Institute of Genetics, Yata, Japan

Features: The PMD covers over 81,000 natural as well as artificial mutants of proteins, including random and site-directed ones, for all proteins except members of the globin and immunoglobulin families. The PMD is based on literature, not on proteins. That is, each entry in the database corresponds to one article which may describe one, several or a number of protein mutants.

Host: The Bioinformatics Group at the IMP Vienna, Austria

Features: PRENbase is an annotated database of known and predicted prenylated proteins. Homologous proteins are merged into clusters. This search interface is designed to allow sophisticated queries for the experimental status of the modification (known/predicted...), exclusive or shared types of modifying enzymes (FT, GGT1, GGT2) as well as for evolutionary conservation by constraining the taxonomic distribution within these clusters or for single sequences.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK and Ghent University in Belgium

Features: The PRIDE PRoteomics IDEntifications database is a centralized, standards compliant, public data repository for proteomics data. It has been developed to provide the proteomics community with a public repository for protein and peptide identifications together with the evidence supporting these identifications. PRIDE is able to capture details of post-translational modifications coordinated relative to the peptides in which they have been found.

Host: European Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: Prosite is a database of protein families and domains. It consists of biologically significant sites, patterns and profiles that help to reliably identify to which known protein family (if any) a new sequence belongs. Users can enter a protein sequence or find out the characteristic motifs of domains.

Host: National Center for Biotechnology Information, Bethesda, MD, USA

Features: RefSeq is a subset of Genbank records that represent reference sequence standards. RefSeq standards are a curated reference data set that avoid the redundancy found in Genbank and provide a stable reference point for mutation studies, expression analysis and homology investigations. RefSeq standards are found for over 3 million proteins, translated mRNAs and genomic data from over 4000 organisms.

Host: Massachusetts Institute of Technology, Beth Israel Deaconess Medical Center, St. Jude's Children's Research Hospital, MA, USA

Features: Scansite searches for motifs within proteins that are likely to be phosphorylated by specific protein kinases or bind to domains such as SH2 domains, 14-3-3 domains or PDZ domains.

Host: Swiss Institute of Bioinformatics, Geneva, Switzerland

Features: Swiss 2D-PAGE contains data on proteins identified on various 2-D PAGE and SDS-PAGE reference maps. Proteins can be located on the 2-D PAGE maps or display the region of a 2-D PAGE map where one might expect to find a protein from Swiss-Prot.

Host: Swiss Institute of Bioinformatics, Geneva, Switzerland

Features: SwissProt is a curated protein sequence database provided by the ExPASy (Expert Protein Analysis System) proteomics server of the Swiss Institute of Bioinformatics (SIB). It strives to provide a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases.

Host: The Institute for Genomics Research, Bethesda, MD, USA

Features: TIGRFAMs are protein families based on Hidden Markov Models or HMMs. Use this page to see the curated seed alignmet for each TIGRFAM, the full alignment of all family members and the cutoff scores for inclusion in each of the TIGRFAMs. Also use this page to search through the TIGRFAMs and HMMs for text in the TIGRFAMs Text Search or search for specific sequences in the TIGRFAMs Sequence Search.

Host: Texas Wesleyan University, Fort Worth, TX, USA

Features: “A Protein Primer” makes music from protein sequences by assigning increasing pitch to amino acids by their increasing hydrophobicity values and the duration of each note is set by the number of codons coding for it.

Host: TEuropean Molecular Biology Lab - European Bioinformatics Institute, Hixton, UK

Features: The UniProt (Universal Protein Resource) for protein sequences and is the central hub for the collection of functional information on proteins, with accurate, consistent, and rich annotation, the amino acid sequence, protein name or description, taxonomic data and citation information. It is a central repository of protein sequence and function created by joining the information contained in UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and PIR.