Our peptide synthesis facility encourages innovative approaches to proteomic discovery and offers screening formats like epitope mapping, peptide library and substitutional analysis for investigation of peptide-protein or protein-protein interactions or the search for bioactive peptides like protein/antibody binding, kinase substrates and others.

We offer a variety of services to meet your peptide array needs:

Epitope Mapping (Peptide Scan) - Design your own custom peptide array for a simple approach to mapping epitopes or other binding areas by a set of overlapping peptides from any protein sequence.

Substitution Analysis (Replacement Scan) - Substitution analysis of a peptide of your interest reveals critical amino acids or possible improvement of binding by amino acid exchanges. The standard peptide array for a substitution analysis would be carried out by systematic substitution of the peptide amino acids by all natural amino acids. The use of other building blocks, such as D-amino acids, unnatural amino acids, and other organic compounds is possible.

Truncation Analysis - The tool of a truncation analysis helps to discover the shortest possible sequence that retains the activity by systematic decreasing of the length of a peptide of your interest from C terminus as well as from N terminus in order.

Random Peptide Library Screening - Synthesis of a random peptide library with your parameters or with one of our standard random peptide libraries with 1200 random 15mer or 12mer peptide sequences in order to identify of bioactive peptides.

Combinatorial Peptide Library Screening - Combinatorial peptide libraries are very useful tools for identification of bioactive peptides starting with a peptide library that represents all possible peptide sequences.

Cluster Peptide Library Screening - Peptide screening starting with a peptide library that consists of random sequences using amino acids clustered by their physiochemical properties (e.g., Asp+Glu, Ile+Leu). It is a very useful alternative peptide screening tool to combinatorial and random peptide library.

Phosphopeptide Library Screening - Phosphopeptide libraries are very useful tools for identification of bioactive phosphopeptides starting with a peptide library that represents all possible phosphopeptide sequences.

Peptide Arrays - Peptide arrays are a powerful tool for the identification of protein-protein interactions, protein-ligand interactions, and the discovery of bioactive peptides. We offer peptide arrays with 12mer, 15mer, and 20mer peptides in a variety of formats including linear, cyclic, and branched peptides. We also offer peptide arrays with modified amino acids including D-amino acids, phosphoamino acids, and other non-natural amino acids.

Peptide Synthesis - We offer custom peptide synthesis services for peptides up to 100 amino acids in length. We can synthesize peptides with a variety of modifications including acetylation, amidation, phosphorylation, biotinylation, and others. We also offer peptide synthesis services for peptides with non-natural amino acids.

Overlay of scanned images of SPOT arrays containing the predicted SARS-CoV-2 peptides (937 overlapping peptides) of the spike protein (Top, outlined in red; receptor binding domain (RBD) outlined in dotted orange), nucleocapsid protein (Middle, outlined in green) and membrane protein (Bottom, outlined in blue), separately probed with serum samples from 10 COVID-19 positive individuals.