Sounds of Cell Signalling Proteins

Kinexus has converted the amino acid sequences and corresponding DNA sequences of the following 12 cell signaling proteins (EGF Receptor, PI 3-Kinase, PTP-1B Phosphatase, VHI-related Phosphatase, PP2B/Calcineurin, Phospholipase A2, PI-specific PLC, cGMP Phosphodiesterase, Adenylate Cyclase, Gi-α1 G Protein, H-Ras, and Caspase 8) into musical notes to produce a unique melody for each protein. The soundtracks are based on the hydrophobicity scores of the amino acids in the primary structure of each protein; the more hydrophilic the amino acid, the higher the musical note that was assigned. The melody notes are of amino acids and background music is of the corresponding DNA. Different scales and tempos were used for the proteins and a selection of different instruments were also employed. The soundtracks were produced by Dr. William Campbell.

Download legend to sound track for all the signal transduction proteins shown immediately below (MIDI FILE FORMAT)