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Sounds of Cell Signalling Proteins

Kinexus has converted the amino acid sequences and corresponding DNA sequences of the following 12 cell signaling proteins (EGF Receptor, PI 3-Kinase, PTP-1B Phosphatase, VHI-related Phosphatase, PP2B/Calcineurin, Phospholipase A2, PI-specific PLC, cGMP Phosphodiesterase, Adenylate Cyclase, Gi-α1 G Protein, H-Ras, and Caspase 8) into musical notes to produce a unique melody for each protein. The soundtracks are based on the hydrophobicity scores of the amino acids in the primary structure of each protein; the more hydrophilic the amino acid, the higher the musical note that was assigned. The melody notes are of amino acids and background music is of the corresponding DNA. Different scales and tempos were used for the proteins and a selection of different instruments were also employed. The soundtracks were produced by Dr. William Campbell.

Download legend to sound track for all the signal transduction proteins shown immediately below (MIDI FILE FORMAT)
Human Epidermal Growth Factor Receptor Tyrosine Kinase Catalytic Domain Erlotinib (Residues 671-998)
Pig Phosphatidylinositol 3-Kinase p110 Catalytic Subunit (Residues 141-1102)
Human Protein-Tyrosine Phosphatase 1B complexed with ETDYpYRKGGKGLL peptide from Insulin Receptor (Residues 1-299)
Human VH1-Related Dual-Specificity Phosphatase VHR complexed with DDEXXGpYVATR substrate peptide (Residues 2-185)
Human Protein-Serine Phosphatase 2B Calcineurin complexed with Calmodulin (Residues 2-185)
Human Phospholipase A2 - IIA (Residues 21-144)
Rat Phosphoinositide-Specific Phospholipase C-delta1 complexed with Inositol-1,4,5-trisphosphate (Residues 133-756)
Dog Adenylate Cyclase V C1A Domain (Residues 445-661) Rat Adenylate Cyclase II C2A Domain (Residues 870-1082) Cow G Protein Gsα Subunit (Residues 1-394)
Human cGMP-specific 3'5' cyclic Phophodiesterase (Residues 537-860)
Rat G Protein Gi-alpha (Residues 1-353)
Human H-Ras (Residues 1-166)
Human Caspase 8 p18 (Residues 211-374) Human Caspase 8 p11 (Residues 385-473) Substrate Peptide - IETD