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Charts & Graphs

Kinexus is pleased to make available a large selection of signal transduction–related slides in Adobe PDF format that may be freely used for teaching purposes. These slides were produced by Kinexus and are copyrighted for commercial purposes. These PDF documents are ready to import into Microsoft PowerPoint Presentations.
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Evolutionary Relatedness Trees for Cell Signalling Proteins

Chart Title
Human 14—3—3 Protein Relatedness Tree
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Human Adenylate and Guanylate Cyclase Catalytic Domains Relatedness Tree
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Human Caspase Catalytic Domains Relatedness Tree
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Human Cyclic Nucleotide Phosphodiesterases Catalytic Domains Relatedness Tree
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Human Cyclin Family Relatedness Tree
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Human Dual Specificity Phosphatase Catalytic Domain Relatedness Tree
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Human G Protein Alpha Subunits Relatedness Tree
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Human PhosphatidylinositolSpecific Phospholipase C Catalytic Domain Relatedness Tree
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Human Phosphatidylinositol 3 KinaseRelated Catalytic Domain Relatedness Tree
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Human Phospholipase A2 Catalytic Domain Relatedness Tree
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Human Protein Kinase Catalytic Domains Relatedness Tree
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Human Ras Family Protein Relatedness Tree
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Human Ras Super Family of Small G Protein Relatedness Tree
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Human Rho Family Protein Relatedness Tree
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Human ProteinSerine Phosphatase Catalytic Domain Relatedness Tree
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Human STAT Protein SH2 Domain Relatedness Tree
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Human ProteinTyrosine Phosphatase Catalytic Domain Relatedness Tree
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Domain Distribution in Cell Signalling Proteins

Chart Title
AGC Group — Human Serine Kinases Domains — 1
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AGC Group — Human Serine Kinases Domains — 2
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AGC Group — Human Serine Kinases Domains — 3
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Ca2+/Calmodulin — Regulated Protein Kinases Domains
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Cyclin — Dependent Kinase Family Domains
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Superfamily of Human Phosphodiesterases
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Human Cyclins Domains
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MAP Kinase Family Domains
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Human Non-Receptor Tyrosine Kinases Domains
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Protein Kinase C Isoforms Domain Structures
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Human Receptor Tyrosine Kinases Domains — 1
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Human Receptor Tyrosine Kinases Domains — 2
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Human Receptor — Serine Kinases
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Structures of Receptor — Tyrosine Kinases
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RGC Group — Human Receptor Serine Kinases Domains
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SH2, PTB and SH3 Domain Interactions
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SH2 and SH3 Domain Distribution in Proteins
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Ste20 Group — Human Serine Kinases Domains — 1
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Ste20 Group — Human ProteinSerine Kinases Domains — 2
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Alignment of Amino Acids in Catalytic Domains of Cell Signalling Proteins

Chart Title
Human Adenylate and Guanylate Cyclase Catalytic Domain Amino Acid Alignment
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Human Caspase Catalytic Domain Amino Acid Alignment
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Human Cyclic Nucleotide Phosphodiesterase Catalytic Domain Amino Acid Alignment
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Human Protein — Tyrosine Phosphatase Catalytic Domain Amino Acid Alignment
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Human G Protein Alpha Subunits Amino Acid Alignment
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Human PI — Specific Phospholipase C Catalytic Domain Amino Acid Alignment
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Human Phosphatidylinositol 3 Kinase-Related Catalytic Domain Amino Acid Alignment
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Human Phospholipase A2 Catalytic Domain Amino Acid Alignment
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Human Protein Kinase Catalytic Domain Amino Acid Alignment
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Human Ras-Related Small G Proteins Amino Acid Alignment
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Human Protein-Serine Phosphatase Catalytic Domain Amino Acid Alignment
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Human Protein-Tyrosine Phosphatase Catalytic Domain Amino Acid Alignment
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Protein Phosphorylation

Chart Title
Human Protein Phosphorylation By Kinases
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Number and Percentage of Tyrosine, Serine and Threonine PhosphoSites
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Human Phosphoproteome — PhosphoSerine and PhosphoThreonine Consensus Phosphorylation Site Frequency
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Human Phosphoproteome — PhosphoTyrosine Consensus Phosphorylation Site Frequency
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Conservation of Human Phospho-Sites in Other Species
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Protein-Serine/Threonine Kinase Consensus Phosphorylation Site Specificity
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Protein Kinases – General

Chart Title
Gender Differences in Protein Kinase Expression Mouse Brain
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Gender Differences in Protein Kinase Expression Mouse Submandibular Gland
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Occurrence of Selected Binding Domains in Protein Kinases
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Commonality of Protein Kinases in Evolution
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Protein Kinases are Major Drug Targets
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Human Protein Kinase Families PhosphoSites Table
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Protein Kinase Inhibitors Approved and in Development
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Tissue Differences in Protein Kinase Protein Expression Part 1
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Tissue Differences in Protein Kinase Protein Expression Part 2
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Kinetworks Multi-Immunoblotting
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Kinetworks PhosphoSite Multi-Immunoblot Jurkat T Cells Staurosporin Treated Overnight
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Protein Kinase Catalytic Domain Conservation Most Evolutionary Conserved Protein Kinases
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Protein Kinase Dimerization
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Protein Kinase Genes in Diverse Genomes Table
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Protein Kinase Networks
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Protein Kinase Chemical Reaction
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Calcium/Calmodulin Regulated Protein Kinase Signalling and PKC

Chart Title
Ca2+/CalmodulinRegulated Protein Kinases 1 + 2 Families
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Ca2+/CalmodulinRegulated Protein Kinases Interactions
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Pathways Leading to Activation of PKC Isoforms
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Mitogen Activated Protein Kinase Signalling

Chart Title
Pathways Leading to Erk2 MAPK Activation
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Examples of Substrates of Erk1 and Erk2 MAPK
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Mammalian MAPK Signalling Pathways
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Sequence Alignment of Activating Phosphorylation Sites in Human MAPK
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Parallel MAPK Pathways in Budding Yeast S. cerevisiae
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Conservation of Ras Signalling Pathways to Erk2 MAPK
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Stimuli Leading to Erk1 and Erk2 MAPK Activation
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Cyclin–Dependent Protein Kinase Signalling

Chart Title
Regulation of Cdc2 kinase in Fission Yeast S. Pombe
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CDK5 Phosphorylation of Tau
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CyclinDependent Kinase Family
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Alignment of Subdomain III Region in Human CyclinDependent Kinases
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Phosphorylation Sites in CyclinDependent Kinases
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Cell Cycle Regulation of CDKs
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Interactions Between Cyclins, CDKs and CyclinDependent Kinase Inhibitors
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Cyclin Expression Levels During HeLa Cell Cycle
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Protein Phosphatases – General

Chart Title
DNA Tumour Virus Protein Interactions with Phosphatase 2A
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Human Protein Protein Phosphatase Families Table
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G Protein Signalling

Chart Title
7TM Receptors Couple to G Proteins Diagram
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G? Protein Couples to Adenylate Cyclase Diagram
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G Protein Stimulation of Phospholipase C Isoforms
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Human Ras Protein Family Gene Expression
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Human Rho Protein Family Gene Expression
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3D Stick Structural Models of Cell Signalling Proteins

Chart Title
?Adrenergic Receptor Kinase (GRK2) binding to G??~1 Stick Model
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?Adrenergic Receptor Kinase (GRK2) binding to G??~1 Stick Model
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Calmodulin 3D Stick Model
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CalmodulinDependent Kinase 2 Holoenzyme Structure Stick Model
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Epidermal Growth Factor binding to EGF Receptor Extracellular Domain 1 Stick Models
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Epidermal Growth Factor binding to EGF Receptor Extracellular Domains 2 Stick Models
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Trimeric G Protein Complex Gt Stick Model
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Vascular Endothelial Growth Factor Binding to VEGF Receptor Stick Models
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Covalent Modification of Cell Signalling Proteins

Chart Title
Examples of Farnesylated Proteins
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Examples of Glycosyl Phosphatidylinositol Anchored Proteins
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Examples of Myristoylated Proteins
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Examples of Palmitoylated Proteins
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Protein Microarrays

Chart Title
Kinex Antibody Microarrays Step 4 Protein Binding to Array
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Kinex Antibody Microarrays Step 3 Incubation with Array
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Kinex Antibody Microarrays Step 1 Protein Lysate
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Kinex Antibody Microarrays Step 2 Protein Labelling
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Kinex Antibody Microarrays Positive and Negative Results
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Kinex Antibody Microarrays Step 5 Removal Unbound Protein and Quantitation
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Reverse Microarray Format
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PanPhospho Antibody in Sandwich Microarray Format
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Miscellaneous

Chart Title
2D Gel Electrophoresis — Siliver Stained
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2D Gel Electrophoresis — Immunoblot
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Examples of Agonists that Induce Phosphatidylcholine Breakdown
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Amino Acid Sequence of Proteins
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Activation of cAMPdependent Protein Kinase
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cGMP Production by ANP Receptor
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Comparative Genomics Across Species
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Desensitization of the ?Adrenergic Receptor
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Gene Families in Human Genome
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Gene (DNA) Microarrays
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Central Dogma of Molecular Biology
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Human Genome Sequencing
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IL3 Receptor Alpha and Common Beta Subunits
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Induction of IL11 and Biological Consequences
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Light Induced Activation of cGMP Phosphodiesterase
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Lipid Signalling Pathways
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Volume Occupied by Major Intracellular Compartments in a Typical Cell
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Examples of Protein and Peptide Extracellular Mediators
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Phenotype Reflects Functional Protein Not mRNA
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Ribosomal Protein S6 Phosphorylation Sites
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Structure of Rous Sarcoma Virus Genome
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Signal Transduction Overview
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Summary of Total Kinase Gene Expression
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Transcriptomics with Gene (DNA) Microarrays
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Credits